If you’re searching for a hearty, flavorful dish that brings comfort and bold southwestern flair to your dinner table, look no further than the John Wayne Casserole Recipe. This casserole is a fantastic blend of seasoned ground beef, cheesy goodness, and a fluffy biscuit base, delivering layers of textures and vibrant tastes that feel like a warm hug on a plate. The combination of tangy sour cream, spicy green chilies, and fresh veggies ensures every bite bursts with familiar, crave-worthy flavors, making it a standout family favorite that’s both satisfying and surprisingly simple to make.

John Wayne Casserole Recipe - Recipe Image

Ingredients You’ll Need

The magic behind the John Wayne Casserole Recipe lies in its straightforward yet perfectly balanced ingredients. Each one adds a unique touch—whether it’s the rich meatiness, the creamy tang, or the golden biscuit topping—together creating a casserole that’s irresistibly delicious.

  • 1 pound ground beef: Provides a hearty, savory base bursting with protein and flavor.
  • 1 packet taco seasoning mix: Brings classic southwestern spices that elevate the beef with zest and warmth.
  • 2/3 cup water: Helps to simmer the seasoned beef to juicy perfection.
  • 1 can (10 ounces) diced tomatoes with green chilies (drained): Adds vibrant color and a slight kick of heat to the casserole.
  • 1/2 cup sour cream: Adds a rich, creamy tang that balances the spices beautifully.
  • 1/2 cup mayonnaise: Contributes moistness and smooth texture to the creamy layer.
  • 1 cup shredded cheddar cheese (divided): Offers melty, sharp flavor that holds every layer together.
  • 1/2 cup shredded Monterey Jack cheese: Adds a mild, buttery richness on top.
  • 1 medium onion (sliced): Brings a natural sweetness and a bit of crunch when baked.
  • 1 green bell pepper (sliced): Provides freshness and subtle earthiness for balance.
  • 1 can (4 ounces) diced green chilies: Introduces additional spicy brightness to the creamy layer.
  • 2 cups Bisquick baking mix: Creates the fluffy biscuit crust that transforms this meal into pure comfort food.
  • 1/2 cup water (for biscuit layer): Combines with the Bisquick to make the dough tender and golden when baked.
  • Salt and pepper to taste: Simple seasonings to enhance all the flavors perfectly.

How to Make John Wayne Casserole Recipe

Step 1: Brown the Beef

Start by heating a skillet over medium heat and cooking your ground beef until it’s nicely browned and no longer pink. Draining off excess grease here is key to keep the casserole from becoming too oily, while retaining that juicy savoriness that sets the foundation of this dish.

Step 2: Season the Beef

Once the beef is cooked, sprinkle in the taco seasoning mix and pour in 2/3 cup of water. Stir it up and let it simmer gently for 5 minutes so all those spices meld into the meat, creating a zesty, flavorful filling that’s bursting with classic southwestern character.

Step 3: Prepare the Biscuit Base

In a separate mixing bowl, combine the Bisquick baking mix with 1/2 cup of water to form a soft dough. This easy dough will be pressed into your baking dish to create the golden, fluffy biscuit layer that’s the perfect contrast to the savory toppings.

Step 4: Assemble the Layers

Grease a 9×13-inch baking dish and press that biscuit dough evenly across the bottom. Next, spoon the seasoned ground beef over the dough, spreading it evenly. Then, mix together sour cream, mayonnaise, half of the cheddar cheese, and diced green chilies, spreading this creamy layer over the beef.

Step 5: Add the Fresh Veggies and Cheese

On top of the creamy spread, layer the sliced onions and green bell peppers evenly. Then, scatter the drained diced tomatoes with green chilies over the veggies, adding a fresh, slightly spicy pop. Finally, sprinkle the remaining cheddar cheese along with the Monterey Jack cheese for that extra melty, golden finish.

Step 6: Bake to Perfection

Pop your assembled casserole into a preheated 350°F oven and bake uncovered for 30 to 35 minutes. You’ll know it’s ready when the cheese is melted and bubbly and the biscuit base turns a tempting golden brown. Let it cool for 5 to 10 minutes before serving to allow the layers to set perfectly.

How to Serve John Wayne Casserole Recipe

John Wayne Casserole Recipe - Recipe Image

Garnishes

Enhance your John Wayne Casserole Recipe with fresh, colorful garnishes like chopped cilantro, sliced jalapeños, or a dollop of guacamole. These additions add brightness, a touch of heat, or creamy coolness to complement the casserole’s rich layers, making each bite more exciting.

Side Dishes

This casserole pairs beautifully with simple sides that balance its hearty richness. Serve with a crisp green salad drizzled with lime dressing or some steamed corn on the cob to add crunch and freshness on the side.

Creative Ways to Present

For a fun twist, try serving your John Wayne Casserole Recipe in individual ramekins for a personal touch, perfect for dinner parties or meal prep. Alternatively, accompany it with warm tortillas to create taco-style scoops that your family will love.

Make Ahead and Storage

Storing Leftovers

Store any leftover John Wayne Casserole Recipe in an airtight container in the refrigerator for up to 3 days. The flavors actually deepen after resting, making those leftovers just as delicious, if not better, than the first serving.

Freezing

If you want to save some for later, this casserole freezes wonderfully. Wrap it tightly in plastic wrap and foil or transfer to a freezer-safe container, where it can be stored for up to 2 months. Just thaw overnight in the fridge before reheating.

Reheating

To reheat, place portions in the oven at 350°F for about 15–20 minutes until warmed through and bubbly again. Microwave reheating works too, but the oven helps maintain that irresistible biscuit crispness on the bottom.

FAQs

Can I use ground turkey or chicken instead of beef?

Absolutely! Ground turkey or chicken are great alternatives that lighten the dish while keeping it tasty. Just follow the same cooking steps and seasoning for equally delicious results.

Is this casserole spicy? Can I adjust the heat level?

This John Wayne Casserole Recipe has a mild, approachable heat from the green chilies and taco seasoning. Feel free to add jalapeños or hot sauce if you like it spicy, or omit the green chilies for a more gentle flavor.

What can I substitute for Bisquick if I don’t have any?

If you don’t have Bisquick, you can make a simple biscuit dough from scratch using all-purpose flour, baking powder, salt, and shortening or butter. Just mix until crumbly and add enough milk or water to form a soft dough.

Can I prepare this recipe ahead of time and bake it later?

Yes! You can assemble the casserole up to the point before baking, cover it tightly, and keep it in the fridge for a few hours or overnight. When you’re ready, bake it as directed, just add a few extra minutes if it’s cold from the fridge.

How many servings does this recipe make?

The John Wayne Casserole Recipe yields about 8 generous servings, perfect for a family dinner or for leftovers to enjoy the next day.

Final Thoughts

You simply cannot go wrong with the John Wayne Casserole Recipe. It’s the kind of dish that feels like a warm embrace after a long day—rich, satisfying, and filled with flavors that everyone will love. I wholeheartedly encourage you to give it a try and watch it quickly become a beloved staple in your recipe rotation!

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John Wayne Casserole Recipe

5 Stars 4 Stars 3 Stars 2 Stars 1 Star 3.9 from 67 reviews
  • Author: admin
  • Prep Time: 20 minutes
  • Cook Time: 35 minutes
  • Total Time: 55 minutes
  • Yield: 8 servings
  • Category: Main Course
  • Method: Baking
  • Cuisine: American

Description

John Wayne Casserole is a hearty and flavorful southwestern-inspired baked dish featuring seasoned ground beef layered with a creamy cheese and green chili mixture, fresh vegetables, and a golden biscuit crust made from Bisquick. This easy-to-make family favorite combines taco seasoning with comforting cheese and vegetable toppings to create a satisfying main course perfect for weeknight dinners or casual gatherings.


Ingredients

Scale

Meat and Seasoning

  • 1 pound ground beef
  • 1 packet taco seasoning mix
  • 2/3 cup water (for seasoning)

Vegetables and Mix-ins

  • 1 can (10 ounces) diced tomatoes with green chilies (drained)
  • 1 medium onion (sliced)
  • 1 green bell pepper (sliced)
  • 1 can (4 ounces) diced green chilies

Dairy and Cheese

  • 1/2 cup sour cream
  • 1/2 cup mayonnaise
  • 1 cup shredded cheddar cheese (divided)
  • 1/2 cup shredded Monterey Jack cheese

Biscuit Crust

  • 2 cups Bisquick baking mix
  • 1/2 cup water (for biscuit layer)

Seasoning

  • Salt and pepper to taste


Instructions

  1. Preheat Oven: Preheat your oven to 350°F (175°C) to prepare for baking the casserole.
  2. Cook Ground Beef: In a skillet over medium heat, brown the ground beef until fully cooked, breaking it up as it cooks. Drain any excess grease to keep the dish from being too oily.
  3. Add Seasoning: Stir in the taco seasoning mix and 2/3 cup water with the cooked beef. Simmer the mixture for 5 minutes to allow the flavors to meld, then remove from heat.
  4. Prepare Biscuit Dough: In a mixing bowl, combine Bisquick baking mix and 1/2 cup water until a soft dough forms. This will serve as the biscuit base for the casserole.
  5. Press Biscuit Base: Grease a 9×13-inch baking dish. Press the biscuit dough evenly into the bottom of the dish to form the crust layer.
  6. Layer Beef: Spread the cooked and seasoned ground beef evenly over the biscuit base.
  7. Mix Cream and Cheese Layer: In a separate bowl, combine sour cream, mayonnaise, 1/2 cup shredded cheddar cheese, and diced green chilies. Spread this creamy mixture evenly over the beef layer.
  8. Add Vegetables: Arrange sliced onions and green bell peppers over the creamy layer, then add the drained diced tomatoes with green chilies on top.
  9. Top with Cheese: Sprinkle the remaining 1/2 cup shredded cheddar cheese and the Monterey Jack cheese evenly over the top of the casserole.
  10. Bake: Bake the casserole uncovered in the preheated oven for 30 to 35 minutes, or until the cheese on top is melted, bubbly, and the biscuit crust is golden brown.
  11. Cool and Serve: Allow the casserole to cool for 5 to 10 minutes before cutting and serving to let the layers set and flavors intensify.

Notes

  • Substitute ground beef with ground turkey or chicken for a lighter variation.
  • Add jalapeños if you prefer a spicier dish.
  • Black olives can be added for extra flavor and texture.
  • This casserole reheats well and is perfect for leftovers.

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